Research Articles
The Afterlife of a Pill: The Hunt for Metoclopramide's Hidden Secrets
Discover how scientists identified novel metoclopramide metabolites using advanced LC-MS/MS technology and what this means for drug safety and personalized medicine.
The Hidden Pathway: How Your Body Processes an HIV Medication
Discover the fascinating metabolic journey of saquinavir, an HIV medication, and the discovery of its α-hydroxyaldehyde pathway mediated by CYP3A4 enzyme.
How a Transcription Factor Controls Our Drug Metabolism
Discover how B-cell lymphoma 6 (BCL6) transcription factor regulates drug metabolism through renal transporters OAT1 and OAT3, explaining sex differences in medication response.
The Secret Conversation: How Your Diet Influences Medication Through Liver Enzymes
Discover how unsaturated fatty acids in your diet affect liver enzymes and drug metabolism through cytochrome P-450 interactions.
Monkeying Around with Medicines: How Genetic Testing in Monkeys Could Revolutionize Human Drug Development
Discover how genotyping cytochrome P450 variants in cynomolgus macaques is advancing drug development and personalized medicine approaches.
The Albumin Effect: How a Common Protein Revolutionizes Drug Metabolism and Interactions
Discover how albumin protein influences fenoprofen metabolism and drug interactions through groundbreaking research on chirality and protein binding.
The Body's Pharmacy: How Your Liver Decodes Muscle Relaxants
Explore the fascinating biochemical journey of zoxazolamine and chlorzoxazone metabolism through the liver's cytochrome P450 system.